Akkermansia muciniphila e fetola microbiota ea mala joang le bophelo bo botle ba metabolism?

Akkermansia muciniphila (e tsejoang haholo e le Akkermansia kapa AKK) ke probiotic ea moloko o latelang e hlahang e le ea phylum Verrucomicrobia . Jwalo ka baktheria ea Gram-negative anaerobic , ka tlhaho e bokella lera la mucus la mala 'me e emela setho sa bohlokoa sa microbiota e phetseng hantle ea mala.

AKK e sebelisa mucin ea mala e le mohloli oa limatlafatsi ha ka nako e ts'oanang e hlohlelletsa tlhahiso ea mucus e ncha, ka hona e thusa ho matlafatsa tšireletso ea mala. Ka mamello ea eona e ikhethang ea oksijene le ho ikamahanya le maemo a tikoloho , AKK e bontša bokhoni bo tšepisang ba ts'ebeliso bophelong bo botle ba mala.

Ka nqane ho lisele tsa baktheria tse phelang, Akkermansia e senyehileng, li-vesicle tse kantle ho sele, le liprotheine tsa lera le ka ntle hape ho bontšitsoe hore ho na le ts'ebetso ea baeloji, e leng se eketsang ts'ebeliso ea eona e ka bang teng ho lijo tse sebetsang, li-supplement tsa lijo, le lihlahisoa tsa probiotic tsa moloko o latelang.
 

Moralo oa Lipatlisiso

E phatlalalitsoe ho Virulence , phuputso ena e kopantse mehlala ea lisele tsa in vitro, lithuto tsa liphoofolo le lipatlisiso tsa kliniki tsa batho ho batlisisa ka botlalo bokhoni ba ts'ebetso ba Akkermansia muciniphila (AKK).

Phuputso e totobatsa karolo e ka bang teng ea AKK ho:

• Ts'ehetso mosebetsi oa thibelo ea mala;
• Ho boloka ho leka-lekana ha microbiota ea mala;
• Ho feto-fetoha likarabo tsa ho ruruha le homeostasis ea 'mele ea ho itšireletsa mafung;
• Ts'ehetso tekanyo ea metabolism ea tsoekere le mafura.

Liphuputso tsena li fana ka temohisiso ea saense mabapi le ts'ebeliso ea AKK e le motsoako oa probiotic oa moloko o latelang bakeng sa bophelo bo botle ba mala le lihlahisoa tsa bophelo bo botle ba metabolism.

Liphetho tsa Lipatlisiso

Setšoantšo sa moralo se bontša mekhoa e ka bang teng ea Akkermansia muciniphila (AKK) ho tšehetsa ho leka-lekana ha ho ruruha ha mala.

AKK e ka thusa ho matlafatsa lera la mucus la mala le ho ntlafatsa tlhahiso ea protheine e tiileng ea manonyeletso , ka hona e ntlafatsa botšepehi ba thibelo ea mala. Ho sa le joalo, AKK e ka laola likarabo tsa 'mele oa ho itšireletsa mafung ka ho fetola litsela tse amanang le lipontšo, e susumetsa ts'ebetso ea macrophage le phapang ea lisele tsa T tse laolang , le ho fokotsa ho lokolloa ha lintlha tse bakang ho ruruha ho tšehetsa homeostasis ea 'mele oa ho itšireletsa mafung.

Ho phaella moo, metabolites tse hlahiswang ke AKK, ho kenyeletswa le di-fatty acid tse kgutshwane (di-SCFA) tse kang propionate le butyrate , di kenya letsoho ho fetoloheng ha microbiota ya mala le ho leka-lekana ha tikoloho ya dikokwana-hloko, ho fana ka tshehetso ya mahlakore a mangata bakeng sa bophelo bo botle ba mala mefuteng ya dipatlisiso ya maemo a ho ruruha ha mala a kang ulcerative colitis le lefu la Crohn.

Lijo tse nang le mafura a mangata li ka sitisa botsitso ba maleng, e leng se lebisang ho endotoxemia ea metabolism , ho bokellana ha mafura a mangata, le ho sitisa metabolism ea lipid.

Ho tlatsetsoa ka Akkermansia muciniphila (AKK) ho bontšitsoe ho tšehetsa ts'ebetso ea thibelo ea mala, ho fokotsa maemo a lipopolysaccharide e potolohang (LPS) , le ho khothaletsa tlhahiso ea peptide-1 e kang glucagon (GLP-1) , ka hona ho kenya letsoho taolong e leka-lekaneng ea adipocyte le metabolism ea matla a 'mele oohle.

Lithuto tsa lipatlisiso li bontša hore mefuta e fapaneng ea AKK, ho kenyeletsoa libaktheria tse phelang, lisele tse pasteurized, le li-vesicles tse tsoang kantle ho 'mele , li ka bontša ts'ebetso ea baeloji le ho tšehetsa ntlafatso ea liparamente tsa metabolism tse amanang le botenya, ho kenyeletsoa boima ba 'mele, pokello ea mafura a' mele le liprofaele tsa lipid.

Moelelong oa lipatlisiso tsa lefu la tsoekere la mofuta oa 2 , Akkermansia muciniphila (AKK) e bontša melemo e ka bang teng ea metabolism ka har'a motsoako oa mala le metabolism.

AKK e tšehetsa botšepehi ba thibelo ea mala 'me e thusa ho fokotsa ho kenella ha mala, ka hona e fokotsa khatello ea metabolism e amanang le ho ruruha ho sa foleng ho bakoang ke endotoxin. Ho sa le joalo, AKK e ka laola likarabo tsa ho ruruha ka tsela ea lipontšo tsa NF-κB , ea tšehetsa kutloisiso ea insulin, le ho khothaletsa tlhahiso ea lihormone tse laolang tsoekere ho boloka botsitso ba metabolism.

Lithuto tse ngata tsa liphoofolo le batho li bontšitse hore bongata ba Akkermansia muciniphila ka maleng bo amahanngoa hampe le maemo a tsoekere maling le matšoao a amanang le ho hanyetsa insulin , e leng se totobatsang AKK e le sepheo sa bohlokoa sa lipatlisiso taolong ea bophelo bo botle ba metabolism.

Kakaretso ea Lipatlisiso

Ka kakaretso, lithuto tse pharaletseng tsa saense li bontšitse hore Akkermansia muciniphila (AKK) e na le litšobotsi tse ngata tse sebetsang, ho kenyeletsoa:

• Ts'ehetso botšepehi ba thibelo ea mala;
• Ho khothalletsa ho leka-lekana ha microbiota ea mala;
• Ho feto-fetoha likarabo tsa ho ruruha;
• Ts'ehetso tekanyo ea metabolism ea tsoekere le mafura;
• Ho laola homeostasis ea 'mele ea ho itšireletsa mafung.

Ka melemo ena e fapaneng ea baeloji, AKK e bontša bokhoni bo tšepisang ba ts'ebeliso bophelong bo botle ba mala, taolo ea boima ba 'mele, bophelo bo botle ba metabolism, le lihlahisoa tsa phepo tse shebaneng le microbiome.

Ka ho sebelisa theknoloji e tsoetseng pele ea ho belisa likokoana-hloko le ho omisa ka serame , Hanhe Biotechnology e fihletse tlhahiso e ka atolosoang ea metsoako ea Akkermansia muciniphila e sebetsang haholo ka botsitso bo botle, ho lumellana ho matla le boleng bo tsitsitseng.

Motsoako ona o ka sebelisoa mafapheng a fapaneng, ho kenyeletsoa lijo tse sebetsang, li-supplement tsa lijo le lihlahisoa tsa bophelo bo botle ba mala , ho fana ka tharollo ea metsoako ea probiotic ea moloko o latelang e tšepahalang le e lumellanang bakeng sa nts'etsopele ea sehlahisoa se secha.

(Sengoloa sena se reretsoe puisano ea saense feela 'me ha se keletso ea bongaka kapa ea bophelo bo botle. Ka kopo buisana le setsebi sa tlhokomelo ea bophelo bo botle se tšoanelehang bakeng sa matšoenyeho afe kapa afe a amanang le bophelo bo botle.)

Reference

Zhao Y, Yang H, Wu P, et al. Akkermansia muciniphila: Probiotic e tšepisang khahlano le ho ruruha le mathata a metabolism[J]. Virulence , 2024, 15(1): 2375555.